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For emergency relief of bronchoconstriction in horses, it is administered by slow intravenous solution at a dilution of 0. 2 mg/50 mL of saline. Administration is discontinued when the heart rate doubles. Terbutaline is a beta 2 -receptor agonist similar to isoproterenol but longer acting (6–8 hours). Clenbuterol: This is a bronchodilator that may be beneficial in treating some horses with Equine Asthma. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. Clenbuterol should only be used short-term, since it will stop working with long-term administration. Clenbuterol is considered a newer-generation bronchodilator used in the treatment of Chronic Obstructive Pulmonary Disease (COPD, also known as "heaves") in horses. It works by relaxing the smooth muscles surrounding the airways and opening the passages. It also loosens excess mucus. Ventipulmin® Syrup (clenbuterol HCl) is a beta-2-adrenergic agonist to provide bronchodilating properties with minimum effect on the cardiovascular system. Ventipulmin® Syrup (clenbuterol HCl) is indicated for the management of horses affected with airway obstruction, such as occurs in chronic obstructive pulmonary disease (COPD). Clenbuterol works by relaxing the smooth muscles surrounding the airways and opening the passages, and also serves to loosen excess mucus. In May of 1998, the U. Food and Drug Administration (FDA) approved a branded variety of clenbuterol syrup for use in horses. Clenbuterol, often given orally as a syrup, is a medication that can be used therapeutically to assist horses with respiratory difficulties
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